CBD oil or dog treats may help your furry best friend get a good night’s rest. But before you go out and purchase a CBD pet product, you’ll need to visit your veterinarian for a full check-up to see whether your dog is in pain.
Dogs like people feel pain when sick or injured. That said, pain management is a routine part of the physical examination and treatment plan in veterinary medicine. With pain comes different types of behaviors linked to a physical problem.
It may be aggression, lethargy, or other behavioral changes. It’s up to each pet parent to be able to recognize the signs of pain in their dogs, since dogs may act differently when in pain. Keep in mind that if your dog is in pain, he may suffer from insomnia.
According to a newstudy about how cannabidiol can help insomnia. The study added that “CBD appears to be better tolerated than routine psychiatric medications. Furthermore, CBD displays promise as a tool for reducing anxiety in clinical populations,” via NCBI.
A 2010 study on the effects of CBD on depression adds that “Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. The effects of CBD may be mediated by the activation of 5-HT(1A) receptors. As 5-HT(1A) receptor activation may induce antidepressant-like effects,” via PubMed.
The aim of the experiment was to” test the hypothesis that CBD would have antidepressant-like activity in mice as assessed by the forced swimming test. We also investigated if these responses depended on the activation of 5-HT(1A) receptors and on hippocampal expression of brain-derived neurotrophic factor (BDNF).”
The results demonstrated that “BD (30 mg*kg (-1)) treatment reduced immobility time in the forced swimming test, as did the prototype antidepressant imipramine, without changing exploratory behavior in the open-field arena. WAY100635 pretreatment blocked CBD-induced effect in the forced swimming test. CBD (30 mg*kg (-1)) treatment did not change hippocampal BDNF levels.
CBD induces antidepressant-like effects comparable to those of imipramine. These effects of CBD were probably mediated by activation of 5-HT(1A) receptors.”
Another interesting 2016 research paper says that CBD induces rapid-acting anti-depressants-like effects and enhances cortical 5- HT/glutamate neurotransmission. (The 5-HT 1A receptor is a subtype of 5-HT, and binds with the neurotransmitter serotonin. It is a main inhibitory G- protein with subtypes found mainly in the neocortex.)
The study explains that “Our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia. In vivo microdialysis revealed that the administration of CBD significantly enhanced serotonin and glutamate levels in vmPFCx in a different manner depending on the emotional state and the duration of the treatment.
The potentiating effect upon neurotransmitters levels occurring immediately after the first injection of CBD might underlie the fast antidepressant-like actions in OBX mice.
Both the antidepressant-like effect and enhanced cortical 5-HT/glutamate neurotransmission induced by CBD were prevented by 5-HT1A receptor blockade. Moreover, adaptive changes in pre- and postsynaptic 5-HT1A receptor functionality were also found after chronic CBD. In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signaling through a 5-HT1A receptor-dependent mechanism, “via PubMed.
Tel Aviv University in a 2014 clinical trial on CBD and its effects on depression adds that a low dosage of THC reduces swelling and inflammation in the brain without psychoactive effects. The researchers also added that CBD has the same properties as THC without the “high” and that it may produce similar outcomes in humans, as it did in the tested mice.